Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma

BACKGROUND: Progressive/recurrent high-grade and diffuse intrinsic pontine gliomas (DIPGs) are fatal. Treatments targeting molecular pathways critical for these cancers are needed. METHODS: We conducted a phase 1 study (rolling-6 design) to establish the safety and maximum tolerated dose (MTD) of da...

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Vydáno v:Pediatr Blood Cancer
Hlavní autoři: Broniscer, Alberto, Jia, Sujuan, Mandrell, Belinda, Hamideh, Dima, Huang, Jie, Onar-Thomas, Arzu, Gajjar, Amar, Raimondi, Susana C., Tatevossian, Ruth G., Stewart, Clinton F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980705/
https://ncbi.nlm.nih.gov/pubmed/29512900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.27035
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