Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice

Bax and Bak are critical effectors of apoptosis. Although both are widely expressed and usually functionally redundant, recent studies suggest that Bak has particular importance in certain cell types. Genetic and biochemical studies indicate that Bak activation is prevented primarily by Mcl-1 and Bc...

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Autors principals: Vandenberg, C J, Josefsson, E C, Campbell, K J, James, C, Lawlor, K E, Kile, B T, Cory, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978304/
https://ncbi.nlm.nih.gov/pubmed/24464220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.201
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