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Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres

BACKGROUND: Notch and Hedgehog signaling have been implicated in the pathogenesis and stem-like characteristics of glioblastomas, and inhibitors of the pathways have been suggested as new therapies for these aggressive tumors. It has also been reported that targeting both pathways simultaneously can...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ding, Dacheng, Lim, Kah Suan, Eberhart, Charles G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977902/
https://ncbi.nlm.nih.gov/pubmed/24685274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-31
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