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Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in the normal brain, and is common in malignant brain tumors. We examined the effects of hypoxia on stem-like cells in glioblastoma (GBM). When GBM-derived neurosphere cultures are grown in 1% oxygen, hypoxia-induci...

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Main Authors: Bar, Eli E., Lin, Alex, Mahairaki, Vasiliki, Matsui, William, Eberhart, Charles G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928980/
https://ncbi.nlm.nih.gov/pubmed/20671264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091021
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