NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

Cancer stem cells (CSCs) are thought to be critical for the engraftment and long-term growth of many tumors, including glioblastoma (GBM). The cells are at least partially spared by traditional chemotherapies and radiation therapies, and finding new treatments that can target CSCs may be critical fo...

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Detalhes bibliográficos
Main Authors: Fan, Xing, Khaki, Leila, Zhu, Thant S., Soules, Mary E., Talsma, Caroline E., Gul, Naheed, Koh, Cheryl, Zhang, Jiangyang, Li, Yue-Ming, Maciaczyk, Jarek, Nikkhah, Guido, DiMeco, Francesco, Piccirillo, Sara, Vescovi, Angelo L., Eberhart, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878196/
https://ncbi.nlm.nih.gov/pubmed/19904829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.254
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