cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

The pattern of neurodegeneration in Alzheimer’s disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. In c...

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Dettagli Bibliografici
Autori principali: Carlyle, Becky C., Nairn, Angus C., Wang, Min, Yang, Yang, Jin, Lu E., Simen, Arthur A., Ramos, Brian P., Bordner, Kelly A., Craft, George E., Davies, Peter, Pletikos, Mihovil, Šestan, Nenad, Arnsten, Amy F. T., Paspalas, Constantinos D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977284/
https://ncbi.nlm.nih.gov/pubmed/24707050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322360111
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