cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

The pattern of neurodegeneration in Alzheimer’s disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. In c...

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Detalhes bibliográficos
Main Authors: Carlyle, Becky C., Nairn, Angus C., Wang, Min, Yang, Yang, Jin, Lu E., Simen, Arthur A., Ramos, Brian P., Bordner, Kelly A., Craft, George E., Davies, Peter, Pletikos, Mihovil, Šestan, Nenad, Arnsten, Amy F. T., Paspalas, Constantinos D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977284/
https://ncbi.nlm.nih.gov/pubmed/24707050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322360111
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