Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans

Age-associated dementia and Alzheimer’s disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related MS and diabetes are also...

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Detalhes bibliográficos
Main Authors: Cai, Weijing, Uribarri, Jaime, Zhu, Li, Chen, Xue, Swamy, Shobha, Zhao, Zhengshan, Grosjean, Fabrizio, Simonaro, Calogera, Kuchel, George A., Schnaider-Beeri, Michal, Woodward, Mark, Striker, Gary E., Vlassara, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977256/
https://ncbi.nlm.nih.gov/pubmed/24567379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316013111
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