Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

BACKGROUND: Advanced glycations end products increase oxidant stress, inflammation, and neurotoxicity. Serum levels are increased in diabetes and aging. We examined the relationship between serum methylglyoxal derivatives (sMG), and cognitive decline, in 267 non-demented elderly. METHODS: Tobit mixe...

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Main Authors: Beeri, Michal Schnaider, Moshier, Erin, Schmeidler, James, Godbold, James, Uribarri, Jaime, Reddy, Sarah, Sano, Mary, Grossman, Hillel T, Cai, Weijing, Vlassara, Helen, Silverman, Jeremy M
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243767/
https://ncbi.nlm.nih.gov/pubmed/22079406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2011.10.007
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