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Decameric SelA•tRNA(Sec) Ring Structure Reveals Mechanism of Bacterial Selenocysteine Formation

The 21st amino acid, selenocysteine (Sec), is synthesized on its cognate transfer RNA (tRNA(Sec)). In bacteria, SelA synthesizes Sec from Ser-tRNA(Sec), whereas in archaea and eukaryotes SepSecS forms Sec from phosphoserine (Sep) acylated to tRNA(Sec). We determined the crystal structures of Aquifex...

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Hlavní autoři: Itoh, Yuzuru, Bröcker, Markus J., Sekine, Shun-ichi, Hammond, Gifty, Suetsugu, Shiro, Söll, Dieter, Yokoyama, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976565/
https://ncbi.nlm.nih.gov/pubmed/23559248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229521
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