Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled...

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Autori principali: Swift, Joe, Ivanovska, Irena L., Buxboim, Amnon, Harada, Takamasa, Dingal, P. C. Dave P., Pinter, Joel, Pajerowski, J. David, Spinler, Kyle R., Shin, Jae-Won, Tewari, Manorama, Rehfeldt, Florian, Speicher, David W., Discher, Dennis E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976548/
https://ncbi.nlm.nih.gov/pubmed/23990565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1240104
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