Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically-induced multistep skin carcinogenesis

BACKGROUND: We have previously reported stromal upregulation of the endogenous angiogenesis inhibitor thrombospondin-2 (TSP-2) during multistep carcinogenesis, and we found accelerated and enhanced skin angiogenesis and carcinogenesis in TSP-2 deficient mice. GOALS: To investigate whether enhanced l...

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Autori principali: Kunstfeld, Rainer, Hawighorst, Thomas, Streit, Michael, Hong, Young-Kwon, Nguyen, Lynh, Brown, Lawrence F., Detmar, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975683/
https://ncbi.nlm.nih.gov/pubmed/24507936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2014.01.002
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