Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis

Genetic and pharmacological evidence suggests that overexpression of cyclooxygenase-2 (COX-2) is critical for epithelial carcinogenesis and provides a major target for cancer chemoprevention by nonsteroidal antiinflammatory drugs. Transgenic mouse lines with keratin 5 promoter-driven COX-2 overexpre...

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Detalhes bibliográficos
Main Authors: Müller-Decker, Karin, Neufang, Gitta, Berger, Irina, Neumann, Melanie, Marks, Friedrich, Fürstenberger, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129471/
https://ncbi.nlm.nih.gov/pubmed/12221288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192323799
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