Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice

The function of the endogenous angiogenesis inhibitor thrombospondin-1 (TSP-1) in tissue repair has remained controversial. We established transgenic mice with targeted overexpression of TSP-1 in the skin, using a keratin 14 expression cassette. TSP-1 transgenic mice were healthy and fertile, and di...

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Udgivet i:EMBO J
Main Authors: Streit, Michael, Velasco, Paula, Riccardi, Lucia, Spencer, Lisa, Brown, Lawrence F., Janes, Lauren, Lange-Asschenfeldt, Bernhard, Yano, Kiichiro, Hawighorst, Thomas, Iruela-Arispe, Luisa, Detmar, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313956/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880440/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.13.3272
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