The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

Increased IL-6 production induces, via STAT3 phosphorylation, hepatic transcription of the gene encoding the iron-regulatory hormone, hepcidin, leading to development of anemia of chronic disease (ACD). Inhibition of bone morphogenetic protein (BMP) signaling prevents the induction of hepcidin gene...

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Detalhes bibliográficos
Main Authors: Mayeur, Claire, Lohmeyer, Lisa K., Leyton, Patricio, Kao, Sonya M., Pappas, Alexandra E., Kolodziej, Starsha A., Spagnolli, Ester, Yu, Binglan, Galdos, Rita L., Yu, Paul B., Peterson, Randall T., Bloch, Donald B., Bloch, Kenneth D., Steinbicker, Andrea U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975261/
https://ncbi.nlm.nih.gov/pubmed/24501215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-480095
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