The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

Increased IL-6 production induces, via STAT3 phosphorylation, hepatic transcription of the gene encoding the iron-regulatory hormone, hepcidin, leading to development of anemia of chronic disease (ACD). Inhibition of bone morphogenetic protein (BMP) signaling prevents the induction of hepcidin gene...

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Autores principales: Mayeur, Claire, Lohmeyer, Lisa K., Leyton, Patricio, Kao, Sonya M., Pappas, Alexandra E., Kolodziej, Starsha A., Spagnolli, Ester, Yu, Binglan, Galdos, Rita L., Yu, Paul B., Peterson, Randall T., Bloch, Donald B., Bloch, Kenneth D., Steinbicker, Andrea U.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975261/
https://ncbi.nlm.nih.gov/pubmed/24501215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-480095
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