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The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6
Increased IL-6 production induces, via STAT3 phosphorylation, hepatic transcription of the gene encoding the iron-regulatory hormone, hepcidin, leading to development of anemia of chronic disease (ACD). Inhibition of bone morphogenetic protein (BMP) signaling prevents the induction of hepcidin gene...
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| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3975261/ https://ncbi.nlm.nih.gov/pubmed/24501215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-480095 |
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