The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

Increased IL-6 production induces, via STAT3 phosphorylation, hepatic transcription of the gene encoding the iron-regulatory hormone, hepcidin, leading to development of anemia of chronic disease (ACD). Inhibition of bone morphogenetic protein (BMP) signaling prevents the induction of hepcidin gene...

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Bibliografiske detaljer
Main Authors: Mayeur, Claire, Lohmeyer, Lisa K., Leyton, Patricio, Kao, Sonya M., Pappas, Alexandra E., Kolodziej, Starsha A., Spagnolli, Ester, Yu, Binglan, Galdos, Rita L., Yu, Paul B., Peterson, Randall T., Bloch, Donald B., Bloch, Kenneth D., Steinbicker, Andrea U.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975261/
https://ncbi.nlm.nih.gov/pubmed/24501215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-480095
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