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Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex

Human T lymphotropic virus type I (HTLV-I) infection is largely latent in infected persons. How HTLV-1 establishes latency and reactivates is unclear. Here we show that most HTLV-1-infected HeLa cells become senescent. By contrast, when NF-κB activity is blocked, senescence is averted, and infected...

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Bibliografiske detaljer
Main Authors: Philip, Subha, Zahoor, Muhammad Atif, Zhi, Huijun, Ho, Yik-Khuan, Giam, Chou-Zen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974842/
https://ncbi.nlm.nih.gov/pubmed/24699669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004040
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