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Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines

The synthesis of α-chiral amines bearing two alkyl groups has been hampered by the accessibility and stability of the alkylimine precursor. Herein, we report an efficient strategy to generate the alkyl-substituted imine in situ that is compatible with the Me-DuPHOS monoxide·Cu(I) catalyzed addition...

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Hlavní autoři: Côté, Alexandre, Boezio, Alessandro A., Charette, André B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC397394/
https://ncbi.nlm.nih.gov/pubmed/15064400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307096101
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