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Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines

The synthesis of α-chiral amines bearing two alkyl groups has been hampered by the accessibility and stability of the alkylimine precursor. Herein, we report an efficient strategy to generate the alkyl-substituted imine in situ that is compatible with the Me-DuPHOS monoxide·Cu(I) catalyzed addition...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Côté, Alexandre, Boezio, Alessandro A., Charette, André B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397394/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15064400/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307096101
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