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Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

INTRODUCTION: Hypoxia-inducible factor (HIF)-1α, part of the heterodimeric transcription factor that mediates the cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment of endothelial progenitor cells. Inhibition of the...

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Autori principali: Zimmermann, Andrew S., Morrison, Shane D., Hu, Michael S., Li, Shuli, Nauta, Allison, Sorkin, Michael, Meyer, Nathaniel P., Walmsley, Graham G., Maan, Zeshaan N., Chan, Denise A., Gurtner, Geoffrey C., Giaccia, Amato J., Longaker, Michael T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973687/
https://ncbi.nlm.nih.gov/pubmed/24695462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093373
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