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An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage
Although engineered nucleases can efficiently cleave intracellular DNA at desired target sites, major concerns remain on potential ‘off-target’ cleavage that may occur throughout the genome. We developed an online tool: predicted report of genome-wide nuclease off-target sites (PROGNOS) that effecti...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973315/ https://ncbi.nlm.nih.gov/pubmed/24381193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1326 |
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