In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

Gene-editing nucleases enable targeted modification of DNA sequences in living cells, thereby facilitating efficient knockout and precise editing of endogenous loci. Engineered nucleases also have the potential to introduce mutations at off-target sites of action. Such unintended alterations can con...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sander, Jeffry D., Ramirez, Cherie L., Linder, Samantha J., Pattanayak, Vikram, Shoresh, Noam, Ku, Manching, Foden, Jennifer A., Reyon, Deepak, Bernstein, Bradley E., Liu, David R., Joung, J. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799455/
https://ncbi.nlm.nih.gov/pubmed/23945932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt716
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados