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Engineering Designer Nucleases with Customized Cleavage Specificities
Engineered designer nucleases can be used to efficiently modify genomic sequence in a wide variety of model organisms and cell types. Zinc finger nucleases (ZFNs), consisting of an engineered zinc finger array fused to a non-specific cleavage domain, have been extensively used to modify a broad rang...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3379964/ https://ncbi.nlm.nih.gov/pubmed/21987054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471142727.mb1213s96 |
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