In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

Gene-editing nucleases enable targeted modification of DNA sequences in living cells, thereby facilitating efficient knockout and precise editing of endogenous loci. Engineered nucleases also have the potential to introduce mutations at off-target sites of action. Such unintended alterations can con...

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Detaylı Bibliyografya
Asıl Yazarlar: Sander, Jeffry D., Ramirez, Cherie L., Linder, Samantha J., Pattanayak, Vikram, Shoresh, Noam, Ku, Manching, Foden, Jennifer A., Reyon, Deepak, Bernstein, Bradley E., Liu, David R., Joung, J. Keith
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Methods Online
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799455/
https://ncbi.nlm.nih.gov/pubmed/23945932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt716
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