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Valproic Acid for the Treatment of Hemorrhagic Shock: A Dose Optimization Study
BACKGROUND: Valproic acid (VPA) has been shown to improve survival in animal models of hemorrhagic shock at 300mg/kg. Our aim was to identify the ideal dose through a dose escalation, split dosing, and dose de-escalation regimen. MATERIALS AND METHODS: Rats were subjected to sublethal 40% hemorrhage...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3972223/ https://ncbi.nlm.nih.gov/pubmed/24135375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.09.016 |
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