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Valproic Acid for the Treatment of Hemorrhagic Shock: A Dose Optimization Study

BACKGROUND: Valproic acid (VPA) has been shown to improve survival in animal models of hemorrhagic shock at 300mg/kg. Our aim was to identify the ideal dose through a dose escalation, split dosing, and dose de-escalation regimen. MATERIALS AND METHODS: Rats were subjected to sublethal 40% hemorrhage...

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Detalhes bibliográficos
Main Authors: Hwabejire, John O., Lu, Jennifer, Liu, Baoling, Li, Yongqing, Halaweish, Ihab, Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972223/
https://ncbi.nlm.nih.gov/pubmed/24135375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.09.016
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