HYPOTHERMIA AND VALPROIC ACID ACTIVATE PRO-SURVIVAL PATHWAYS AFTER HEMORRHAGE

BACKGROUND: Therapeutic hypothermia (Hypo) and valproic acid (VPA, a histone deacetylase inhibitor) have independently been shown to be protective in models of trauma and hemorrhagic shock (HS), but require logistically challenging doses to be effective. Theoretically, combined treatment may further...

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Detalhes bibliográficos
Publicado no:J Surg Res
Main Authors: Bambakidis, Ted, Dekker, Simone E., Liu, Baoling, Maxwell, Jake, Chatraklin, Kiril, Linzel, Durk, Li, Yongqing, Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606462/
https://ncbi.nlm.nih.gov/pubmed/25777823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2015.02.036
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