IDENTIFICATION OF THE GPR55 ANTAGONIST BINDING SITE USING A NOVEL SET OF HIGH POTENCY GPR55 SELECTIVE LIGANDS

GPR55 is a Class A G protein-coupled receptor (GPCR) that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development and cancer. Initially deorphanized as a cannabinoid receptor, GPR55 has been shown to be activated by non-cannabinoid ligands such as L-α-lysopho...

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Autors principals: Kotsikorou, Evangelia, Sharir, Haleli, Shore, Derek M., Hurst, Dow P., Lynch, Diane L., Madrigal, Karla E., Heynen-Genel, Susanne, Milan, Loribelle B., Chung, Thomas D.Y., Seltzman, Herbert H., Bai, Yushi, Caron, Marc G., Barak, Larry S., Croatt, Mitchell P., Abood, Mary E., Reggio, Patricia H.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970910/
https://ncbi.nlm.nih.gov/pubmed/24274581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4008885
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