Striatal Synaptosomes from Hdh(140Q/140Q) Knock-in Mice have Altered Protein Levels, Novel Sites of Methionine Oxidation, and Excess Glutamate Release after Stimulation

BACKGROUND: Synaptic connections are disrupted in patients with Huntington’s disease (HD). Synaptosomes from postmortem brain are ideal for synaptic function studies because they are enriched in pre- and post-synaptic proteins important in vesicle fusion, vesicle release, and neurotransmitter recept...

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Huvudupphovsmän: Valencia, Antonio, Sapp, Ellen, Kimm, Jeffrey S., McClory, Hollis, Ansong, Kwadwo A., Yohrling, George, Kwak, Seung, Kegel, Kimberly B., Green, Karin M., Shaffer, Scott A., Aronin, Neil, DiFiglia, Marian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970728/
https://ncbi.nlm.nih.gov/pubmed/24696705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-130080
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