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Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wabl, M, Burrows, P D, von Gabain, A, Steinberg, C
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397062/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3918310/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.2.479
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