Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

BACKGROUND & AIMS: Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silenci...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Peterson, Anthony J., Menheniott, Trevelyan R., O’Connor, Louise, Walduck, Anna K., Fox, James G., Kawakami, Kazuyuki, Minamoto, Toshinari, Ong, Eng Kok, Wang, Timothy C., Judd, Louise M., Giraud, Andrew S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2010
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970568/
https://ncbi.nlm.nih.gov/pubmed/20801119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.08.043
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