Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

BACKGROUND & AIMS: Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silenci...

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Main Authors: Peterson, Anthony J., Menheniott, Trevelyan R., O’Connor, Louise, Walduck, Anna K., Fox, James G., Kawakami, Kazuyuki, Minamoto, Toshinari, Ong, Eng Kok, Wang, Timothy C., Judd, Louise M., Giraud, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970568/
https://ncbi.nlm.nih.gov/pubmed/20801119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.08.043
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