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STRUCTURE-GUIDED RATIONAL DESIGN OF α/β-PEPTIDE FOLDAMERS WITH HIGH AFFINITY FOR BCL-2 FAMILY PRO-SURVIVAL PROTEINS
We have used computational methods to improve the affinity of a foldamer ligand for its target protein. The effort began with a previously reported α/β-peptide based on the BH3 domain of the pro-apoptotic protein Puma; this foldamer binds tightly to Bcl-x(L) but weakly to Mcl-1. The crystal structur...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970217/ https://ncbi.nlm.nih.gov/pubmed/23929624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300351 |
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