TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms

Enhanced proliferative signaling and loss of cell cycle regulation are essential for cancer progression. Increased mitogenic signaling through activation of the mTOR pathway, coupled with deregulation of the Cyclin D/retinoblastoma (Rb) pathway is a common feature of lymphoid malignancies, including...

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Detaylı Bibliyografya
Asıl Yazarlar: Simmons, John K., Patel, Jyoti, Michalowski, Aleksandra, Zhang, Shuling, Wei, Bih-Rong, Sullivan, Patrick, Gamache, Ben, Felsenstein, Kenneth, Kuehl, W. Michael, Simpson, R. Mark, Zingone, Adriana, Landgren, Ola, Mock, Beverly A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2013
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969848/
https://ncbi.nlm.nih.gov/pubmed/24429254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.11.007
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