Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

[Image: see text] The transcription factor MYC plays a pivotal role in cancer initiation, progression, and maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC. One attractive route to pharmacological inhibition of MYC has been the prevention of its expression th...

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Publicat a:ACS Chem Biol
Autors principals: Felsenstein, Kenneth M., Saunders, Lindsey B., Simmons, John K., Leon, Elena, Calabrese, David R., Zhang, Shuling, Michalowski, Aleksandra, Gareiss, Peter, Mock, Beverly A., Schneekloth, John S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719142/
https://ncbi.nlm.nih.gov/pubmed/26462961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00577
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