A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

SIMPLE SUMMARY: The DNA G-quadruplex (G4) present in the promoter of the MYC oncogene, commonly amplified in cancers, including multiple myeloma, represents a potential anti-cancer target. A previously identified MYC G4-stablizer, which demonstrated cytotoxicity and senescence in myeloma cells, was...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Gaikwad, Snehal M., Phyo, Zaw, Arteaga, Anaisa Quintanilla, Gorjifard, Sayeh, Calabrese, David R., Connors, Daniel, Huang, Jing, Michalowski, Aleksandra M., Zhang, Shuling, Liu, Zheng-Gang, Schneekloth, John S., Mock, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650714/
https://ncbi.nlm.nih.gov/pubmed/33066043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102952
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