Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe D...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185959/
https://ncbi.nlm.nih.gov/pubmed/30315240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06315-w
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