Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes

Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA-binding specificity. Here, we use custom DNA microarrays to examine the binding specificities...

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Publicado no:ACS Chem Biol
Main Authors: Ray, Sreejana, Tillo, Desiree, Boer, Robert E., Assad, Nima, Barshai, Mira, Wu, Guanhui, Orenstein, Yaron, Yang, Danzhou, Schneekloth, John S., Vinson, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263473/
https://ncbi.nlm.nih.gov/pubmed/32216326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00934
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