TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms

Enhanced proliferative signaling and loss of cell cycle regulation are essential for cancer progression. Increased mitogenic signaling through activation of the mTOR pathway, coupled with deregulation of the Cyclin D/retinoblastoma (Rb) pathway is a common feature of lymphoid malignancies, including...

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Detalhes bibliográficos
Main Authors: Simmons, John K., Patel, Jyoti, Michalowski, Aleksandra, Zhang, Shuling, Wei, Bih-Rong, Sullivan, Patrick, Gamache, Ben, Felsenstein, Kenneth, Kuehl, W. Michael, Simpson, R. Mark, Zingone, Adriana, Landgren, Ola, Mock, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969848/
https://ncbi.nlm.nih.gov/pubmed/24429254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.11.007
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