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Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology
Amyloid formation in the pancreas by islet amyloid polypeptide (IAPP) leads to β-cell death and dysfunction, contributing to islet transplant failure and to type-2 diabetes. IAPP is stored in the β-cell insulin secretory granules and cosecreted with insulin in response to β-cell secretagogues. IAPP...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969731/ https://ncbi.nlm.nih.gov/pubmed/23266002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2012.11.003 |
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