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Dependency of the Spindle Assembly Checkpoint on Cdk1 Renders the Anaphase Transition Irreversible
Activation of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) by Cdc20 is delayed by the spindle assembly checkpoint (SAC). When all kinetochores come under tension, the SAC is turned off and APC/C(Cdc20) degrades cyclin B and securin, which activates separase [1]. The latter then cleaves cohesi...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cell Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969274/ https://ncbi.nlm.nih.gov/pubmed/24583015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.01.033 |
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