Dependency of the Spindle Assembly Checkpoint on Cdk1 Renders the Anaphase Transition Irreversible

Activation of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) by Cdc20 is delayed by the spindle assembly checkpoint (SAC). When all kinetochores come under tension, the SAC is turned off and APC/C(Cdc20) degrades cyclin B and securin, which activates separase [1]. The latter then cleaves cohesi...

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Auteurs principaux: Rattani, Ahmed, Vinod, P.K., Godwin, Jonathan, Tachibana-Konwalski, Kikuë, Wolna, Magda, Malumbres, Marcos, Novák, Béla, Nasmyth, Kim
Format: Artigo
Langue:Inglês
Publié: Cell Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969274/
https://ncbi.nlm.nih.gov/pubmed/24583015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.01.033
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