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System-level feedbacks make the anaphase switch irreversible

The mitotic checkpoint prevents a eukaryotic cell from commencing to separate its replicated genome into two daughter cells (anaphase) until all of its chromosomes are properly aligned on the metaphase plate, with the two copies of each chromosome attached to opposite poles of the mitotic spindle. T...

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Autori principali: He, Enuo, Kapuy, Orsolya, Oliveira, Raquel A., Uhlmann, Frank, Tyson, John J., Novák, Béla
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116408/
https://ncbi.nlm.nih.gov/pubmed/21617094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102106108
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