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Irreversibility of mitotic exit is the consequence of systems level feedback

The eukaryotic cell cycle comprises an ordered series of events, orchestrated by the activity of cyclin-dependent kinases (Cdks), leading from chromosome replication during S-phase to their segregation in mitosis. The unidirectionality of cell cycle transitions is fundamental for successful completi...

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Detalhes bibliográficos
Main Authors: López-Avilés, Sandra, Kapuy, Orsolya, Novák, Béla, Uhlmann, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817895/
https://ncbi.nlm.nih.gov/pubmed/19387440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07984
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