DNA methylation is required for the control of stem cell differentiation in the small intestine

The mammalian intestinal epithelium has a unique organization in which crypts harboring stem cells produce progenitors and finally clonal populations of differentiated cells. Remarkably, the epithelium is replaced every 3–5 d throughout adult life. Disrupted maintenance of the intricate balance of p...

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Bibliographic Details
Main Authors: Sheaffer, Karyn L., Kim, Rinho, Aoki, Reina, Elliott, Ellen N., Schug, Jonathan, Burger, Lukas, Schübeler, Dirk, Kaestner, Klaus H.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
Subjects:
Resource/Methodology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967052/
https://ncbi.nlm.nih.gov/pubmed/24637118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.230318.113
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