Obesity and lipid stress inhibit carnitine acetyltransferase activity

Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase (PDH),...

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Autori principali: Seiler, Sarah E., Martin, Ola J., Noland, Robert C., Slentz, Dorothy H., DeBalsi, Karen L., Ilkayeva, Olga R., An, Jie, Newgard, Christopher B., Koves, Timothy R., Muoio, Deborah M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966698/
https://ncbi.nlm.nih.gov/pubmed/24395925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M043448
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