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Metabolic profiling of PPARα(−/−) mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
Peroxisome proliferator-activated receptor-α (PPARα) is a master transcriptional regulator of β-oxidation and a prominent target of hypolipidemic drugs. To gain deeper insights into the systemic consequences of impaired fat catabolism, we used quantitative, mass spectrometry-based metabolic profilin...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The Federation of American Societies for Experimental Biology
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630792/ https://ncbi.nlm.nih.gov/pubmed/18945875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-119420 |
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