Metabolic profiling of PPARα(−/−) mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

Peroxisome proliferator-activated receptor-α (PPARα) is a master transcriptional regulator of β-oxidation and a prominent target of hypolipidemic drugs. To gain deeper insights into the systemic consequences of impaired fat catabolism, we used quantitative, mass spectrometry-based metabolic profilin...

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Главные авторы: Makowski, Liza, Noland, Robert C., Koves, Timothy R., Xing, Weibing, Ilkayeva, Olga R., Muehlbauer, Michael J., Stevens, Robert D., Muoio, Deborah M.
Формат: Artigo
Язык:Inglês
Опубликовано: The Federation of American Societies for Experimental Biology 2009
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630792/
https://ncbi.nlm.nih.gov/pubmed/18945875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-119420
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