Network quantification of EGFR signaling unveils potential for targeted combination therapy

The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small-molecule drugs targeting this network are increasingly available. However, often only specific combinations of inhibitors are effective. Therefore, the prediction of potent combinatorial treatm...

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Detalhes bibliográficos
Main Authors: Klinger, Bertram, Sieber, Anja, Fritsche-Guenther, Raphaela, Witzel, Franziska, Berry, Leanne, Schumacher, Dirk, Yan, Yibing, Durek, Pawel, Merchant, Mark, Schäfer, Reinhold, Sers, Christine, Blüthgen, Nils
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964313/
https://ncbi.nlm.nih.gov/pubmed/23752269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.29
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