Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kinase in the...

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Huvudupphovsmän: Fritsche-Guenther, Raphaela, Witzel, Franziska, Sieber, Anja, Herr, Ricarda, Schmidt, Nadine, Braun, Sandra, Brummer, Tilman, Sers, Christine, Blüthgen, Nils
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130559/
https://ncbi.nlm.nih.gov/pubmed/21613978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.27
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