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Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kinase in the...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130559/ https://ncbi.nlm.nih.gov/pubmed/21613978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.27 |
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