Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

Targeted therapies within the RAS/RAF/MEK/ERK signalling axis become increasingly popular, yet cross-talk and feedbacks in the signalling network lead to unexpected effects. Here we look systematically into how inhibiting RAF and MEK with clinically relevant inhibitors result in changes in PI3K/AKT...

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Publicat a:Oncotarget
Autors principals: Fritsche-Guenther, Raphaela, Witzel, Franziska, Kempa, Stefan, Brummer, Tilman, Sers, Christine, Blüthgen, Nils
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884967/
https://ncbi.nlm.nih.gov/pubmed/26799289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6959
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